|
T11282 |
FGTI-2734
|
|
Transferase
|
|
|
|
T6302 |
Lonafarnib
|
Sarasar,Sch66336 |
Raf
,
Transferase
,
Autophagy
,
Ras
|
|
Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM). |
|
T2678 |
LB42708
|
|
Transferase
|
|
|
|
T3182 |
L-778123 hydrochloride
|
L 778123 |
Telomerase
,
Transferase
|
|
The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination. |
|
T2700 |
FTI-277 hydrochloride
|
FTI 277 HCl |
Apoptosis
,
Transferase
,
Ras
|
|
FTI-277 hydrochloride (FTI 277 HCl) is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely related GGTase I. |
|
T38050 |
CP-609754
|
|
Transferase
|
|
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 n... |
|
T6271 |
Tipifarnib
|
R115777,Zarnestra,IND 58359 |
Transferase
|
|
Tipifarnib (IND 58359) is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnes... |
|
T17102 |
Tipifarnib (S enantiomer)
|
Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer |
Transferase
|
|
Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM). |
|
T26012 |
R 115777
|
R115777,R-115777 |
|
|
R 115777 is an inhibitor of farnesyl transferase. |
|
T24356 |
L 739749
|
L 739,749,L739749,L-739749,L-739,749,L739,749 |
|
|
L 739749 is a CAAX peptidomimetic. It is also an inhibitor of farnesyl-protein transferase. |
|
T26347 |
Zaragozic acid D
|
|
|
|
Zaragozic acid D inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger. |
|
T10223 |
ABT-100
|
|
Others
|
|
ABT-100 is a potent, highly selective, and orally active farnesyl transferase inhibitor with broad-spectrum antitumor activity. |
|
T26348 |
Zaragozic acid D(2)
|
|
|
|
Zaragozic acid D(2) inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger. |
|
T11330L |
FTI-2148
|
|
Others
|
|
FTI-2148 is an inhibitor of RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) (IC50s: 1.4 nM and 1.7 μM, respectively). |
|
T70157 |
GGTI-297
|
|
|
|
GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase). |
|
T35433 |
α-hydroxy Farnesyl Phosphonic Acid
|
|
|
|
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations greater than 1 μM, α-hydroxy farnesyl phos... |
|
T11330 |
FTI-2148 diTFA
|
|
Others
|
|
FTI-2148 diTFA, a dual inhibitor targeting both farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1), functions as a RAS C-terminal mimetic. It exhibits potent inhibitory capabilities with IC50 values of ... |
|
T11282L |
FGTI-2734 mesylate (1247018-19-4 free base)
|
FGTI-2734 mesylate |
Others
|
|
FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates ... |
|
T62135 |
Tubulin polymerization-IN-25
|
|
|
|
Tubulin polymerization-IN-25 is a selective, dual tubulin polymerization (IC50: 1.11 μM) and farnesyl transferase (FTase) (IC50: 0.39 μM) inhibitor. polymerization-IN-25 exhibits cytotoxicity against cancer cells and blo... |
|
T10567 |
BMS-214662
|
|
Raf
|
|
BMS-214662 is a potent and selective farnesyl transferase inhibitor that induces mitochondrial apoptosis in primitive CD34+ chronic myeloid leukemia (CML) stem cells/progenitors, and has the ability to selectively target... |
|
T72707 |
(Rac)-Lonafarnib
|
Sch66336 racemate |
|
|
(Rac)-Lonafarnib (Sch66336 racemate) is the racemic form of the potent, orally active farnesyl transferase (FTase) inhibitor, Lonafarnib. It effectively inhibits H-ras, K-ras, and N-ras with IC50 values of 1.9 nM, 5.2 nM... |
|
T69618 |
XR3054
|
|
|
|
XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 (IC50 values of 12.4, 12.... |
